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This chapter provides commentary on Article 45 of the CoE Convention against Trafficking, which deals with the reservations and states that no reservation may be made in respect of any provision of this Convention. It begins with a short introduction, generally providing an overview of the main issues covered by the chapter. It then reviews the drafting history or preparatory work of the provision; provides a comparative analysis of this provision in the context of other international or regional legal instruments focused on human trafficking; and finally discusses the interpretation of the text and the legal issues.