Until recently, entrepreneurship and neighbourhood studies were academic disciplines which rarely interacted with each other. However, recent macroeconomic and societal trends have pointed the spotlight on the nexus between entrepreneurship, neighbourhoods and communities, highlighting not only the importance of ‘the local’ in entrepreneurship, but also the huge gaps in our knowledge base regarding this tripartite relationship. In much of the literature, a distinction is drawn between entrepreneurship taking place in neighbourhoods or communities, and entrepreneurship taking place for neighbourhoods and communities. This chapter starts out from the international call for interdisciplinary approaches to entrepreneurship and firm formation to overcome entrepreneurship research and neighbourhood and community studies’ mutual neglect for one another’s fields of research. This introduction to a volume of chapters aims to shed light on the multiple relationships between entrepreneurship, neighbourhoods and communities across several countries. It asks how neighbourhoods and communities can shape entrepreneurship, a question for which the relevance stems from radical changes of (inter)national and regional labour markets and growing evidence that neighbourhood contexts impact on entrepreneurship and self-employment in various ways. It also asks the ‘reverse’ question: how does entrepreneurship influence neighbourhoods and communities? In doing so, the chapter (and many other chapters in the book) treat ‘community’ as a local, spatially embedded concept. Particular attention is devoted to community-based forms of enterprise and their potential for contemporary bottom-up neighbourhood regeneration.