Many remarkable social and political developments have recently struck Argentina, Bolivia, Chile and Uruguay. What has been the role of Civil Society Organizations (CSOs) in these events? Before and during the pandemic, how have non-profit organizations interacted with State actors? With thorough reading of texts and interviews with well-known civil society experts in the region some revealing findings are presented, providing new paths for scholars and practitioners. In some cases traditional CSOs are left behind by social protests claiming for change, which were organized by informal networks. In other examples territorial social organizations articulated rapidly with national and local State actors during the pandemic but are now worried if things will go back to ignoring them as usual. The impact of these new circumstances remains to be seen and analyzed.