This chapter explores how Appreciative Inquiry (AI) can inform research on change and innovation for greater ethics, sustainability and responsibility. After briefly detailing the underlying principles of AI, we explore the links between these principles and responsible management scholarship. We demonstrate how AI draws attention to at least three aspects of responsible managers’ approaches to pursuing change, namely: (1) the language managers use as they communicate about change and attempt to engage others; (2) the nature of the vision guiding managers’ change efforts; and (3) the extent to which they rely on of multi-stakeholder dialogue and co-creation. We then provide two brief cases to illustrate how AI has been applied to create responsible change management and innovation. The chapter concludes with suggestions for future research leveraging AI to further expand the theory and practice of responsible management.