The concept of resilience has attracted increasing interest in regional economics. In the flourishing literature, however, results are mixed, even when referring to the same case study. This mixed evidence stems also from different operationalization of the multifaceted resilience concept; the main difference being between studies using gross domestic product (GDP) series and those measuring regional economic performance in terms of fluctuations in employment levels. It is important, therefore, to address what kind of relationship – if any – exists between the two measures. To this end, the chapter analyses and compares results concerning regional resilience in Italy over the last 40 years, focusing on the differences deriving from the choice between the two aforementioned measures. The analysis reveals that the information contained in the different series are not alternative and overlapping but complementary.