This chapter asks, ‘How does an academic entrepreneur pursue responsible research commercialisation?’ Section 13.1 briefly describes the research frontier on academic entrepreneurship and argues for new knowledge on how university-based scientists can commercialise in a responsible way. Section 13.2 describes the empirical context, focusing on UK healthcare digitalisation and the academic policy context. Section 13.3 briefly describes a framework and methodology, followed by the narrative case study discussion in Section 13.4. The narrative case study identifies how this entrepreneur achieves his goals in the academic context and explains the barriers to technology commercialisation. This case also assesses the level of responsibility associated with the professor’s innovation and examines the importance of a psychological contract for an academic with an insecure position. Section 13.5 discusses the impact of our findings on current UK policy and practice and Section 13.6 concludes by highlighting the implications and considerations for theory and practice.