This chapter explores how civic leadership can be considered an important element in economic resilience and the ways in which local stakeholders view their institutional environments and economic cultures. Civic leadership provides a lens to think about the role of governance in shaping the form and direction of regional resilience. The chapter specifically explores the importance of partnerships spanning across political, bureaucratic and business leaders and how these connections can help navigate regional economic policy and the strategic goals of social and economic development. The case of the Sheffield City Region, a once thriving manufacturing hub of northern England, is presented as an example of how the collaboration of stakeholders and the Local Enterprise Partnerships is crucial in enabling resilience in a changing economic and social landscape.