Recent research shows that many patients and caregivers develop innovative solutions to cope with their health disorders. Nevertheless, this innovation presents low diffusion. We use a two-stage approach to discuss three research questions: Do these individuals play a role in health innovation? What are their motivations? Could an online, free-access platform promote patient-driven innovations diffusion? We discuss these questions through 11 case studies focusing on innovations by patients and caregivers. Consequently, we analyse data from www.patient-innovation.com, an online platform for innovation sharing. The concept of patient innovation is a good example of Responsible Research and Innovation (RRI). The European Union endorses it and would like to implement and generalize the concept. The objective is to assess implications and societal expectations with regard to research and innovation, and foster the design of inclusive and sustainable research and innovation. A discussion on how Patient Innovation can contribute to RRI in healthcare ends this chapter.