Although technology entrepreneurship has recently received increased attention, the link between entrepreneurship education and the transfer and commercialization of technology has not been explored sufficiently so far. In this chapter the authors apply an explorative approach to investigate two cases of science and technology entrepreneurship education (STEE) by analysing documents and interviews regarding similarities and differences of the two educational programmes. Their findings suggest that open and problem-based pedagogical approaches are more applied in STEE-related courses compared to regular engineering courses. Additionally, STEE benefits greatly from taking place in a practical context with access to support structures that assist in developing technical and business aspects of start-ups. The findings hold implications for research, educational programmes, policy makers and entrepreneurs.