Knowledge-intensive sectors are a significant interest both for regional planners and policy makers, as they promise better jobs and economic growth. The industry is characteristically a networked industry of a large number of clusters, where new clusters from emerging countries continuously join. The industrial spatial structure has changed significantly, after almost every major policy change or crisis. While some clusters seem to dominate and persist, others have been lost at the expense of emerging clusters. This study attempts to focus on the software industry in Turkey, where the industry has multiple locations. The resilience of the industry seems to be highly dependent on the changes in the global industrial structure, economic and policy shocks, and state support. Depending on an adaptive resilience perspective and on an extensive literature survey, expert opinions and secondary data, the study finds that mixed peripherality–core properties, creation and retention of variation, knowledge spillovers and anticipatory behaviors of actors in the industry all play critical roles on the resilience of local software clusters. Findings of the study suggest that policy makers should not adopt generic strategies but focus on well-defined targets and unique strategies regarding the life cycle of the subject industry.