This chapter proposes that bioinspired management and innovation, with foundations in life science and systems thinking, engenders an insightful and bioinclusive approach to the practice of responsible management. Responsible management is grounded in three main tenants: Responsibility, Sustainability, and Ethics. In parallel, biomimicry positions nature as “Model, Measure, and Mentor”. This chapter analyzes how responsibility relates to nature as model, sustainability relies on nature as measure, and ethics calls on nature as mentor. It includes a general overview of biomimicry, some current case studies, and common critiques. It closes with future directions for the study of biomimicry in the context of responsible management.